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B12 is an essential water-soluble vitamin, also known as cobalamin, responsible for critical functions like red blood cell formation, brain health, and DNA synthesis

In the early 1900s, with the advent of new medical therapies and disease perspectives, novel strategies were employed to promote weight loss including thyroid hormone supplementation, and later, amphetamines [1]

Acetylcholine acts through nicotinic receptors to enhance the firing rate of a subset of hypocretin neurons in the mouse hypothalamus through distinct presynaptic and postsynaptic mechanisms

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